RESUMO
The pancreatic ductal tree conveys enzymatic acinar products to the duodenumand secretes the fluid and ionic components of pancreatic juice. The physiology ofpancreatic duct cells has been widely studied, but many questions are still unansweredconcerning their mechanisms of ionic transport. Differences in the transportmechanisms operating in the ductal epithelium has been described both among differentspecies and in the different regions of the ductal tree. In this review we summarizethe methods developed to study pancreatic duct secretion both in vivo and invitro, the different mechanisms of ionic transport that have been reported to date inthe basolateral and luminal membranes of pancreatic ductal cells and the regulationof pancreatic duct secretion by nervous, endocrine and paracrine influences(AU)
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Assuntos
Animais , Transporte de Íons/fisiologia , Pâncreas Exócrino/fisiologia , Ductos Pancreáticos , Técnicas de Cultura de Células/métodos , Membrana Celular/fisiologia , Hormônios Gastrointestinais/fisiologia , Ductos Pancreáticos/fisiologia , Comunicação Parácrina/fisiologia , Secretina/fisiologia , Bombas de Íon/fisiologia , Ductos Pancreáticos/citologia , Ductos Pancreáticos/inervação , Comunicação Parácrina , Perfusão/métodos , Sistema Nervoso Periférico/fisiologia , Punções/métodos , Secretina/metabolismo , Modelos AnimaisRESUMO
The pancreatic ductal tree conveys enzymatic acinar products to the duodenum and secretes the fluid and ionic components of pancreatic juice. The physiology of pancreatic duct cells has been widely studied, but many questions are still unanswered concerning their mechanisms of ionic transport. Differences in the transport mechanisms operating in the ductal epithelium has been described both among different species and in the different regions of the ductal tree. In this review we summarize the methods developed to study pancreatic duct secretion both in vivo and in vitro, the different mechanisms of ionic transport that have been reported to date in the basolateral and luminal membranes of pancreatic ductal cells and the regulation of pancreatic duct secretion by nervous, endocrine and paracrine influences.
